For the first time, a pig kidney has been transplanted into a human without triggering immediate rejection by the recipient’s immune system.
A potentially major advance that could eventually help alleviate a dire shortage of human organs for transplant.
The procedure done at NYU Langone Health in New York City involved use of a pig whose genes had been altere. So that its tissues no longer contained a molecule known to trigger almost immediate rejection.
For three days, new kidney was to attached to her blood vessels and maintained outside her body, giving researchers access to it.
Test results of the transplanted kidney’s function “looked pretty normal,” said transplant surgeon Dr. Robert Montgomery, who led the study.
According to the United Network for Organ Sharing
In the United States, nearly 107,000 people are presently waiting for organ transplants including more than 90,000 awaiting a kidney. According to the United Network for Organ Sharing. Wait times for a kidney average three-to-five years.
The kidney made “the amount of urine that you would expect” from a transplanted human kidney.
There was no evidence of the vigorous, early rejection seen when unmodified pig kidneys are to transplanted into non-human primates.
The recipient’s abnormal creatinine level – an indicator of poor kidney function – returned to normal after the transplant, Montgomery said.
Researchers have been working for decades on the possibility of using animal organs for transplants. But have been stymied over how to prevent immediate rejection by the human body.
Montgomery’s team theorized that knocking out the pig gene for a carbohydrate that triggers rejection. A sugar molecule, or glycan, called alpha-gal – would prevent the problem.